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Renal infarct in a COVID-19-positive kidney-pancreas transplant recipient

Jieqing J Xu1, Daniel Samaha2, Suhas Mondhe2

  • 1Department of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|June 3, 2020
PubMed

Insights

COVID-19 can increase blood clot risk, even after symptoms resolve. A kidney-pancreas transplant patient experienced a renal infarct 26 days post-COVID-19, suggesting a persistent hypercoagulable state.

Area of Science:

  • Nephrology
  • Transplant Surgery
  • Infectious Diseases

Background:

  • COVID-19 is linked to a higher risk of thromboembolic events.
  • The duration and extent of the post-COVID-19 hypercoagulable state are not well understood.
  • Solid organ transplant recipients may face unique risks.

Observation:

  • A 46-year-old kidney-pancreas transplant recipient developed renal allograft infarction.
  • The patient had no prior history of thromboembolism.
  • The infarction occurred 26 days after a COVID-19 diagnosis, while the patient was symptom-free and tested negative for SARS-CoV-2.

Findings:

  • This case report highlights the potential for a persistent hypercoagulable state following COVID-19 infection.
  • Renal allograft infarction can occur in transplant recipients after COVID-19 recovery.

Implications:

  • Further research is needed to understand the long-term thrombotic risks associated with COVID-19 in transplant patients.
  • Guidelines for thromboprophylaxis duration and indications in solid organ transplant recipients post-COVID-19 require further investigation.

Keywords:
clinical research/practiceinfection and infectious agents - viralkidney transplantation/ nephrologythrombosis and thromboembolism

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