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Related Concept Videos

Flow Cytometry01:23

Flow Cytometry

15.3K
The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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Related Experiment Video

Updated: Dec 20, 2025

Immunophenotyping and Cell Sorting of Human MKs from Human Primary Sources or Differentiated In Vitro from Hematopoietic Progenitors
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Immunophenotyping and Cell Sorting of Human MKs from Human Primary Sources or Differentiated In Vitro from Hematopoietic Progenitors

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Reimagining Flow Cytometric Cell Sorting.

Suwan N Jayasinghe1

  • 1BioPhysics Group, Centre for Stem Cells and Regenerative Medicine, Institute of Healthcare Engineering and Department of Mechanical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.

Advanced Biosystems
|June 3, 2020
PubMed
Summary
This summary is machine-generated.

Flow cytometry technology has advanced with novel sheathless flow cells, simplifying systems and reducing size. This versatile innovation supports diverse applications in cell analysis and sorting.

Keywords:
FACSaerodynamically assisted biojetscell sortingflow cellssheathless flow cytometrysingle cell diagnostics

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Purification of Specific Cell Population by Fluorescence Activated Cell Sorting FACS

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Area of Science:

  • Biotechnology
  • Analytical Chemistry
  • Cell Biology

Background:

  • Flow cytometry revolutionized high-throughput single cell analysis.
  • It merges physical sciences with life sciences for cross-disciplinary research.
  • Focus on advancements in flow cell technologies is critical for future development.

Observation:

  • Traditional flow cytometry relies on liquid sheath flow.
  • Recent advancements introduce sheathless flow cell technology.
  • This novel approach eliminates the need for liquid sheath flow.

Findings:

  • Sheathless flow cells reduce the physical footprint of flow cytometry systems.
  • The technology simplifies the design and operation of flow cells.
  • This advancement offers flexibility in handling heterogeneous cell populations and whole organisms.

Implications:

  • Enables more compact and accessible flow cytometry instrumentation.
  • Broadens the applicability of flow cytometry and fluorescent-activated cell sorting.
  • Facilitates advanced single cell analysis in both research and clinical settings.