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Published on: March 18, 2015
A Systematic Review of the Anti-inflammatory Effects of Gallium Compounds
Victor de Albuquerque Wanderley Sales1, Taysa Renata Ribeiro Timóteo1, Natália Millena da Silva1
1Laboratorio de Tecnologia dos Medicamentos, Federal University of Pernambuco (UFPE), Recife-PE, Brazil.
Background:
Inflammation is an essential response provided by the immune system, ensuring the survival during microbial infection, tissue injury and other noxious conditions. However, prolonged inflammatory processes are often associated with severe side effects on health.
Objective:
This systematic review aimed to provide the evidence in the literature of the preclinical and human anti-inflammatory activity of gallium compounds from 2000 to 2019 focused on elucidating the mechanisms involved in the inflammatory process.
Methods:
Seven bibliographical databases were consulted (PubMed, Medline, ScienceDirect, Scopus, Springer, Web of Science, and EBSCOhost). The selection of appropriate publications and writing of this systematic review were based on the guidelines mentioned in the PRISMA statement. Moreover, the assessment of the methodological quality of the selected studies was also performed.
Results:
From a total of 3018 studies, 16 studies were included in this paper based on our eligibility criteria, which showed promising and consistent results.
Conclusion:
Further research concerning specific inflammatory conditions is required.
Insights
Gallium compounds show promising anti-inflammatory effects in preclinical and human studies. Further research is needed to explore their potential for specific inflammatory conditions.
Area of Science:
- Immunology
- Pharmacology
- Materials Science
Background:
- Inflammation is a critical immune response but prolonged inflammation causes severe health issues.
- Understanding inflammatory mechanisms is key to developing new therapies.
Purpose of the Study:
- To systematically review preclinical and human studies on gallium compounds' anti-inflammatory activity.
- To elucidate the mechanisms of action for gallium compounds in inflammation.
- To cover literature published between 2000 and 2019.
Main Methods:
- A comprehensive literature search was conducted across seven major bibliographical databases.
- Study selection and review followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines.
- Methodological quality assessment of included studies was performed.
Main Results:
- Out of 3018 initial studies, 16 met the eligibility criteria for inclusion.
- The selected studies demonstrated consistent and promising anti-inflammatory results for gallium compounds.
- Evidence suggests potential therapeutic applications for gallium in managing inflammatory processes.
Conclusions:
- Gallium compounds exhibit notable anti-inflammatory potential.
- Further investigation into specific inflammatory conditions is warranted.
- Targeted research can optimize gallium-based therapies.
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