The impact of embryo binucleation depends upon its origin
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Updated: Dec 20, 2025

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development
Published on: January 26, 2013
Lia Mara Gomes Paim1, Greg FitzHarris1,2
1Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.
Summary:
Preimplantation embryos frequently contain binucleated cells, but reports differ as to whether binucleation affects development and whether such embryos should be used clinically. In this Point Of View article, we propose a possible explanation for this disparity: binucleation can arise by distinct routes, one that produces healthy blastomeres and one that directly threatens embryo viability.
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