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Linaridin natural products
1Department of Chemistry, Fudan University, Shanghai, 200433, China. qizhang@sioc.ac.cn.
Natural Product Reports
|June 3, 2020
Summary
Linaridins are a diverse group of natural products. Their unique dehydration enzymes and widespread occurrence present intriguing research opportunities in peptide biosynthesis.
Area of Science:
- Natural Product Chemistry
- Biochemistry
- Molecular Biology
Background:
- Linaridins are a class of ribosomally synthesized and post-translationally modified peptides (RiPPs).
- While few linaridins are characterized, in silico studies reveal widespread occurrence and structural diversity.
- Their dehydroamino acid formation involves distinct enzymes, unlike other RiPPs.
Purpose of the Study:
- To review structural features, classification, and biosynthesis of linaridins.
- To discuss the widespread natural occurrence and engineering potential of linaridins.
- To highlight unresolved questions in linaridin maturation.
Main Methods:
- In silico analysis of linaridin occurrence.
- Review of existing literature on linaridin structure and biosynthesis.
- Comparative analysis with other dehydroamino acid-containing RiPPs.
Main Results:
- Linaridins are a widespread and diverse family of RiPPs.
- Dehydroamino acid biosynthesis in linaridins is mediated by unique enzymes.
- Significant knowledge gaps exist regarding linaridin maturation pathways.
Conclusions:
- Linaridins represent a significant, yet underexplored, family of natural products.
- Further research into linaridin-specific enzymes is crucial for understanding their biosynthesis.
- The structural diversity and unique biosynthetic routes offer potential for peptide engineering.
