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Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues

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Linaridin natural products.

Suze Ma¹, Qi Zhang¹

¹Department of Chemistry, Fudan University, Shanghai, 200433, China. qizhang@sioc.ac.cn.

Natural Product Reports

|June 3, 2020

Summary

Linaridins are a diverse group of natural products. Their unique dehydration enzymes and widespread occurrence present intriguing research opportunities in peptide biosynthesis.

Area of Science:

Natural Product Chemistry
Biochemistry
Molecular Biology

Background:

Linaridins are a class of ribosomally synthesized and post-translationally modified peptides (RiPPs).
While few linaridins are characterized, in silico studies reveal widespread occurrence and structural diversity.
Their dehydroamino acid formation involves distinct enzymes, unlike other RiPPs.

Purpose of the Study:

To review structural features, classification, and biosynthesis of linaridins.
To discuss the widespread natural occurrence and engineering potential of linaridins.
To highlight unresolved questions in linaridin maturation.

Main Methods:

In silico analysis of linaridin occurrence.
Review of existing literature on linaridin structure and biosynthesis.

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Comparative analysis with other dehydroamino acid-containing RiPPs.

Main Results:

Linaridins are a widespread and diverse family of RiPPs.
Dehydroamino acid biosynthesis in linaridins is mediated by unique enzymes.
Significant knowledge gaps exist regarding linaridin maturation pathways.

Conclusions:

Linaridins represent a significant, yet underexplored, family of natural products.
Further research into linaridin-specific enzymes is crucial for understanding their biosynthesis.
The structural diversity and unique biosynthetic routes offer potential for peptide engineering.