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Related Experiment Video

Updated: Jun 22, 2026

Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue

Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue

Published on: October 29, 2012

A Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy.

Daniel Boon Loong Teh¹, Akshaya Bansal², Chou Chai^3,4

¹Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117456, Singapore.

Advanced Materials (Deerfield Beach, Fla.)

|June 3, 2020

Summary

New biocompatible implants containing upconversion nanoparticles (UCNPs) enable wireless phototherapy for deep tumors. This overcomes UCNP retention issues, allowing safe, noninvasive treatment for conditions like glioblastoma multiforme.

Keywords:

hydrogels optical fibers photodynamic therapy upconversion wireless operation

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Area of Science:

Biomedical Engineering
Nanotechnology
Photomedicine

Background:

Upconversion nanoparticles (UCNPs) convert near-infrared (NIR) light to visible light for deep-tissue phototherapies.
Clinical translation of UCNPs is limited by retention issues and lack of removal options.
Wireless phototherapy offers advantages for treating deep-sited tumors, including glioblastoma multiforme (GBM).

Purpose of the Study:

To develop a biocompatible UCNP implant for wireless deep-tissue phototherapy.
To address the challenge of UCNP retention and enable safe clinical translation.
To demonstrate the efficacy of NIR-activated photodynamic therapy (PDT) using the UCNP implant.

Main Methods:

Constructed UCNP implants with a poly(ethylene glycol) diacrylate (PEGDA) core and fluorinated ethylene propylene (FEP) cladding.
Tuned UCNP emission spectra to match the absorption of 5-aminolevulinic acid (5-ALA).
Evaluated wireless light transmission and PDT efficacy in a mouse xenograft GBM model.

Main Results:

Developed flexible, biocompatible UCNP implants capable of wireless light transmission up to 8 cm.
Demonstrated successful NIR-based chronic PDT in an untethered and noninvasive manner.
Showcased the potential for UCNP sequestration without compromising light delivery.

Conclusions:

Encapsulated UCNP implants represent a significant advancement for wireless deep-tissue phototherapy.
This approach enables safe and effective phototherapy for deep-sited tumors by managing UCNP retention.
The developed system facilitates untethered, noninvasive chronic PDT, paving the way for clinical translation.