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Fabrication of Biologically Derived Injectable Materials for Myocardial Tissue Engineering

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Injectable Functional Biomaterials for Minimally Invasive Surgery.

Maria Grazia Raucci¹, Ugo D'Amora¹, Alfredo Ronca¹

¹Institute of Polymers, Composites and Biomaterials, National Research Council (IPCB-CNR), Viale J.F. Kennedy 54, Mostra d'Oltremare Pad.20, Naples, 80125, Italy.

Advanced Healthcare Materials

|June 3, 2020

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Injectable biomaterials offer minimally invasive surgical solutions. This review covers advances in calcium phosphate cements and injectable hydrogels for enhanced orthopedic and biomedical applications.

Area of Science:

Biomaterials Science
Minimally Invasive Surgery
Orthopedic Surgery

Background:

Injectable biomaterials are crucial for minimally invasive surgery, with applications in treating vertebral fractures, craniofacial defects, and tumor resections.
Calcium phosphate cements have been extensively used in orthopedic surgery for over 40 years due to their biocompatibility and osteoconductivity.
Limitations of traditional calcium phosphate cements include high viscosity, slow degradation, and handling difficulties.

Purpose of the Study:

To review the current state of the art in injectable biomaterials for minimally invasive surgery.
To highlight recent advances in calcium phosphate cements and injectable hydrogels.
To discuss strategies for overcoming limitations of existing injectable materials.

Main Methods:

Keywords:

hydrogels injectable biomaterials minimally invasive surgery sol-gels tissue engineering

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Review of recent scientific literature on injectable biomaterials.
Analysis of calcium phosphate cements and sol-gel technology.
Examination of injectable hydrogel advancements, including double network hydrogels.

Main Results:

Sol-gel technology shows promise for synthesizing improved injectable calcium phosphate-based materials.
Injectable hydrogels, particularly double network types, offer advantages due to their extracellular matrix-like structure and in situ cross-linking capabilities.
Recent developments focus on overcoming the limitations of traditional injectable biomaterials.

Conclusions:

Injectable biomaterials are vital for advancing minimally invasive surgical procedures.
Continued research into novel materials like modified calcium phosphates and advanced hydrogels is essential.
Future directions include optimizing injectability, degradation, and cell protection for enhanced clinical outcomes.