Clinical presentation and outcomes of adults with bicuspid aortic valves: 2020 update

Li-Tan Yang1, Christophe Tribouilloy2, Ahmad Masri3

  • 1Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.

Insights

Bicuspid aortic valve (BAV) patients with typical presentations have normal survival if complications are treated. Complex BAV presentations or late diagnosis may lead to reduced survival, highlighting research needs.

Area of Science:

  • Cardiology
  • Genetics
  • Vascular Biology

Background:

  • Congenital bicuspid aortic valve (BAV) is a complex condition with varied presentations.
  • Understanding these presentations is key to managing BAV-related valvulo-aortopathy.
  • BAV affects aortic valve structure and the aorta itself.

Purpose of the Study:

  • To review the different presentations of BAV valvulo-aortopathy.
  • To elucidate the burden of BAV-related complications in typical presentations.
  • To discuss survival implications for various BAV patient groups.

Main Methods:

  • Literature review of BAV presentations and outcomes.
  • Analysis of complication data in typical BAV presentations.
  • Discussion of survival data comparing BAV patients to the general population.

Main Results:

  • Typical BAV presentations, when managed promptly, allow for normal long-term survival.
  • Serious complications like endocarditis and dissection are infrequent in BAV.
  • Complex BAV presentations or delayed care can result in a survival penalty.

Conclusions:

  • Timely identification and treatment of complications are crucial for BAV patients with typical presentations.
  • Further research into preventing and treating common BAV complications like valve dysfunction and aortic dilation is needed.
  • BAV patients with complex presentations or delayed care require specialized management strategies to mitigate survival risks.

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