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Updated: Dec 20, 2025

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
Insights into incretin-based therapies for treatment of diabetic dyslipidemia
Kerstin Stemmer1, Brian Finan2, Richard D DiMarchi3
1Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany; Helmholtz Diabetes Center & German Center for Diabetes Research (DZD), Helmholtz Zentrum München, Neuherberg, Germany; Department of Biology, University of Konstanz, Konstanz, Germany.
Abstract:
Derangements in triglyceride and cholesterol metabolism (dyslipidemia) are major risk factors for the development of cardiovascular diseases in obese and type-2 diabetic (T2D) patients. An emerging class of glucagon-like peptide-1 (GLP-1) analogues and next generation peptide dual-agonists such as GLP-1/glucagon or GLP-1/GIP could provide effective therapeutic options for T2D patients. In addition to their role in glucose and energy homeostasis, GLP-1, GIP and glucagon serve as regulators of lipid metabolism. This review summarizes the current knowledge in GLP-1, glucagon and GIP effects on lipid and lipoprotein metabolism and frames the emerging therapeutic benefits of GLP-1 analogs and GLP-1-based multiagonists as add-on treatment options for diabetes associated dyslipidemia.
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