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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: Dec 20, 2025

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy.

Pengfei Zhao¹, Meng Wang¹, Mian Chen²

¹Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, PR China.

|June 3, 2020

Summary

This summary is machine-generated.

This study introduces a novel biomimetic nanoparticle (BNP) that triggers pyroptosis, a highly inflammatory cell death, to enhance immunotherapy for solid tumors. This approach effectively combats both primary and distant tumors by stimulating a systemic immune response.

Keywords:

Biomimetic nanoparticles Immunotherapy Pyroptosis Solid tumor Synergy

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Area of Science:

Biomedical Engineering
Cancer Research
Immunology

Background:

Immunotherapy is effective for some cancers but limited for solid tumors.
Conventional therapies often induce non-inflammatory cell death, hindering immune response.
Pyroptosis, a pro-inflammatory programmed cell death, offers potential for solid tumor immunotherapy.

Purpose of the Study:

To design a biomimetic nanoparticle (BNP) for photo-activated pyroptosis in solid tumors.
To enhance systemic antitumor immunity and overcome immunotherapy limitations in solid tumors.

Main Methods:

Developed a BNP by fusing breast cancer membrane onto a PLGA core, loaded with indocyanine green (ICG) and decitabine (DCT).
Utilized low-dose NIR photo-activation to induce pyroptosis via ICG-mediated calcium increase and caspase-3 activation.
Employed DCT to upregulate GSDME expression, enhancing pyroptosis.

Main Results:

BNPs effectively accumulated in tumors with low immunogenicity.
Photo-activated pyroptosis was successfully induced, leading to cancer cell death.
This pyroptosis triggered significant systemic antitumor immunity, inhibiting both primary and distant tumors.

Conclusions:

The pyroptosis-associated BNP is a novel strategy for solid tumor immunotherapy.
This approach demonstrates high compatibility and wide clinical applicability for enhancing cancer treatment.