Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

176
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
176
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

158
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
158
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

157
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
157
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

125
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
125
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

134
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
134
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

1.8K
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety of antithrombotic therapy in subjects with hereditary hemorrhagic telangiectasia: prospective data from a multidisciplinary working group.

Orphanet journal of rare diseases·2019
Same author

Stool for fecal microbiota transplantation should be classified as a transplant product and not as a drug.

United European gastroenterology journal·2019
Same author

Lung and Gut Microbiota as Potential Hidden Driver of Immunotherapy Efficacy in Lung Cancer.

Mediators of inflammation·2019
Same author

Oral supplementation with lactobacilli to prevent colorectal cancer in preclinical models.

Minerva gastroenterologica e dietologica·2019
Same author

Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions.

Nutrients·2019
Same author

The Association of Disease Activity, BMI and Phase Angle with Vitamin D Deficiency in Patients with IBD.

Nutrients·2019

Related Experiment Video

Updated: Dec 20, 2025

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.0K

Acute Diverticulitis in Elderly Patients: Does Age Really Matter?

Marcello Covino1, Fausto Rosa2, Veronica Ojetti1,3

  • 1Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.

Digestive Diseases (Basel, Switzerland)
|June 3, 2020
PubMed
Summary

Elderly patients (≥80 years) with acute diverticulitis (AD) face higher mortality and complication rates. These older adults present differently, with less fever and pain but more bleeding, indicating a need for tailored care strategies.

Keywords:
Acute diverticulitisElderly patientsMorbidityMortality

More Related Videos

Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis
04:05

Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis

Published on: June 30, 2023

2.6K

Related Experiment Videos

Last Updated: Dec 20, 2025

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.0K
Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis
04:05

Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis

Published on: June 30, 2023

2.6K

Area of Science:

  • Gastroenterology
  • Geriatric Medicine
  • Clinical Outcomes Research

Background:

  • Acute diverticulitis (AD) management in the elderly is debated, with varying clinical outcomes reported.
  • Geriatric populations present unique challenges in disease presentation and progression.

Purpose of the Study:

  • To compare clinical outcomes of acute diverticulitis (AD) between patients aged up to 80 years and those aged 80 years and older.
  • To identify differences in presentation, complications, and mortality between these geriatric cohorts.

Main Methods:

  • A comparative study involving 1,139 patients with AD.
  • 276 patients aged ≥80 years were compared to 863 patients aged <80 years.
  • Primary outcome: overall mortality. Secondary outcomes: major complications, length of stay (LOS), and surgical intervention rates.

Main Results:

  • Patients aged ≥80 years showed less fever and abdominal pain but higher rates of digestive tract bleeding and fatigue.
  • Older patients experienced significantly higher median LOS, cumulative major complications, and mortality rates.
  • Absence of abdominal pain and dyspnea were independent predictors of adverse outcomes in older AD patients.

Conclusions:

  • Acute diverticulitis (AD) in patients aged ≥80 years is associated with increased mortality and major complications compared to younger individuals.
  • Invasive treatments correlated with poorer prognosis in the very elderly AD cohort.
  • Age is a critical factor influencing AD severity and outcomes in geriatric patients.