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Related Concept Videos

Exercise and Cardiac Output01:17

Exercise and Cardiac Output

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Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
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Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
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Related Experiment Video

Updated: Dec 20, 2025

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
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Exercise-Induced Circulating Irisin Level Is Correlated with Improved Cardiac Function in Rats.

Dae Yun Seo1,2, Jun Hyun Bae3, Tae Nyun Kim1,2

  • 1National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea.

International Journal of Environmental Research and Public Health
|June 4, 2020
PubMed
Summary

Regular exercise increases irisin levels in rats, reducing body fat and cholesterol. This elevation in irisin correlates with improved cardiac function, highlighting its role in exercise benefits.

Keywords:
cardiac functionexerciseirisinpro-inflammatory cytokines

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Area of Science:

  • Exercise physiology
  • Cardiovascular research
  • Endocrinology

Background:

  • Irisin is a myokine involved in energy homeostasis.
  • The impact of exercise on irisin and cardiac function requires further investigation.

Purpose of the Study:

  • To examine the effects of a 12-week exercise regimen on irisin levels, pro-inflammatory cytokines, and cardiac function in rats.
  • To explore the correlation between exercise-induced irisin changes and cardiac performance.

Main Methods:

  • Male Sprague-Dawley rats were divided into sedentary control and exercise groups.
  • The exercise group underwent treadmill training for 12 weeks.
  • Measurements included body fat, cholesterol, irisin levels, and cardiac function parameters.

Main Results:

  • Exercise significantly reduced abdominal visceral and epididymal fat, and total cholesterol.
  • Irisin levels were significantly elevated in the exercise group.
  • Irisin levels negatively correlated with fat mass and positively correlated with ejection fraction, fractional shortening, and cardiac output.

Conclusions:

  • Exercise training in rats leads to decreased fat mass and improved cardiac function.
  • Elevated irisin levels may mediate these beneficial effects of exercise.
  • Exercise-induced irisin is linked to enhanced cardiac performance in rats.