Related Experiment Video For fatty acid β-oxidation
Updated: Dec 20, 2025

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
Published on: March 24, 2023
Lipid Metabolism in Development and Progression of Hepatocellular Carcinoma
Moris Sangineto1, Rosanna Villani1, Francesco Cavallone1
1Centro Universitario per la Ricerca e la Cura delle Epatopatie (C.U.R.E.), Liver Unit, Università di Foggia, 71100 Foggia, Italy.
Abstract:
: Metabolic reprogramming is critically involved in the development and progression of cancer. In particular, lipid metabolism has been investigated as a source of energy, micro-environmental adaptation, and cell signalling in neoplastic cells. However, the specific role of lipid metabolism dysregulation in hepatocellular carcinoma (HCC) has not been widely described yet. Alterations in fatty acid synthesis, β-oxidation, and cellular lipidic composition contribute to initiation and progression of HCC. The aim of this review is to elucidate the mechanisms by which lipid metabolism is involved in hepatocarcinogenesis and tumour adaptation to different conditions, focusing on the transcriptional aberrations with new insights in lipidomics and lipid zonation. This will help detect new putative therapeutic approaches in the second most frequent cause of cancer-related death.
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