Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sanger Sequencing01:57

Sanger Sequencing

771.8K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
771.8K
RNA-seq03:21

RNA-seq

11.6K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
11.6K
Next-generation Sequencing03:00

Next-generation Sequencing

97.2K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
97.2K
Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

12.4K
In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...
12.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcome of Prostaglandin E1 Therapy in Critical Lower Limb Ischemia.

Cureus·2026
Same author

Enterovirus 71 seropositivity among children and adolescents in Bangladesh.

IJID regions·2025
Same author

Assessment of potentially toxic element contents in chickens and poultry feeds from Bangladesh markets: Implications for human health risk.

Toxicology reports·2024
Same author

Correction to "Electrochemical Sodiation Mechanism in Magnetite Nanoparticle-Based Anodes: Understanding of Nanoionics-Based Sodium Ion Storage Behavior of Fe<sub>3</sub>O<sub>4</sub>".

ACS applied materials & interfaces·2023
Same author

Electrochemical Sodiation Mechanism in Magnetite Nanoparticle-Based Anodes: Understanding of Nanoionics-Based Sodium Ion Storage Behavior of Fe<sub>3</sub>O<sub>4</sub>.

ACS applied materials & interfaces·2022
Same author

Diabetes IN hospital - Glucose and Outcomes in the COVID-19 pandemic (DINGO COVID-19): the 2020 Melbourne hospital experience prior to novel variants and vaccinations.

Internal medicine journal·2022
Same journal

Correction: Komatsu et al. Three-Dimensional Visualization and Detection of the Pulmonary Venous-Left Atrium Connection Using Artificial Intelligence in Fetal Cardiac Ultrasound Screening. <i>Bioengineering</i> 2026, <i>13</i>, 100.

Bioengineering (Basel, Switzerland)·2026
Same journal

Comparison of CO<sub>2</sub> Laser and Microdebrider in the Surgical Treatment of Pediatric Recurrent Respiratory Papillomatosis: A Retrospective Analysis.

Bioengineering (Basel, Switzerland)·2026
Same journal

Toward More Translational Tumor Models: Breast dECM-Based 3D Systems Capture Native Microenvironmental Cues.

Bioengineering (Basel, Switzerland)·2026
Same journal

Postural Stability Changes During the 4 Phases of the Half Squat: Kinematics Profile of the Center of Pressure and Center of Mass in High-Performance Weightlifters-A Pilot Study.

Bioengineering (Basel, Switzerland)·2026
Same journal

Definite Implant Position as Novel Readout for Effectiveness of Ridge Preservation Indicates to Beneficial Effect of Combined Treatment with Platelet-Rich Fibrin (PRF) and Xenogenic Biomaterial in Bone Regeneration.

Bioengineering (Basel, Switzerland)·2026
Same journal

Trueness and Precision of Intraoral Scanners for 3D-Printed Orthodontic Models with Attachments: An In Vitro Comparative Study.

Bioengineering (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Dec 20, 2025

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
06:40

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome

Published on: March 22, 2018

6.1K

VLSI Structures for DNA Sequencing-A Survey.

Mohammad A Islam1, Palash K Datta1, Harley Myler1

  • 1Phillip M. Drayer Department of Electrical Engineering, Lamar University, Beaumont, TX 77705, USA.

Bioengineering (Basel, Switzerland)
|June 4, 2020
PubMed
Summary
This summary is machine-generated.

This review covers VLSI biosensors for DNA sequencing, highlighting advancements in accuracy and speed. A new approach using Gate All-Around nanowire transistors shows promise for future biomedical research.

Keywords:
DNA hybridizationDNA sensorDNA sequencingGAA nanowire MOSFET

More Related Videos

Rare Event Detection Using Error-corrected DNA and RNA Sequencing
10:36

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

12.4K
A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

8.9K

Related Experiment Videos

Last Updated: Dec 20, 2025

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
06:40

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome

Published on: March 22, 2018

6.1K
Rare Event Detection Using Error-corrected DNA and RNA Sequencing
10:36

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

12.4K
A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

8.9K

Area of Science:

  • Biomedical Engineering
  • Genomics
  • Materials Science

Background:

  • DNA sequencing is crucial for biomedical research and human health.
  • Advances in sequencing technology are needed for greater accuracy, throughput, and speed.

Purpose of the Study:

  • To review Very Large Scale Integration (VLSI) biosensors for nucleotide detection and DNA sequencing.
  • To discuss implementation strategies and architectures for these biosensors.
  • To introduce novel sequencing approaches.

Main Methods:

  • Literature review of VLSI biosensor designs for DNA sequencing.
  • Analysis of function-specific architectures.
  • Introduction of Gate All-Around (GAA) nanowire Metal Oxide Semiconductor Field Effect Transistors (MOSFETs) for sequencing.

Main Results:

  • VLSI biosensors offer potential for improved DNA sequencing.
  • Various implementation strategies and architectures exist for biosensor designs.
  • GAA nanowire MOSFETs represent a promising new direction for DNA sequencing technology.

Conclusions:

  • VLSI biosensors are advancing DNA sequencing capabilities.
  • Continued development of novel architectures, such as GAA nanowire MOSFETs, will impact biomedical research and human health.