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Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
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Implementation of patient-based real-time quality control.

Tony Badrick1, Andreas Bietenbeck2, Alex Katayev3

  • 1RCPA Quality Assurance Programs, St Leonards, Australia.

Critical Reviews in Clinical Laboratory Sciences
|June 4, 2020
PubMed
Summary
This summary is machine-generated.

Patient-based quality control offers a feasible alternative to traditional methods in clinical chemistry, addressing limitations of synthetic controls and improving assay bias detection. This approach enhances the reliability of routine testing.

Keywords:
Optimizationaverage of normalmoving averagequality controlsimulation

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Area of Science:

  • Clinical Chemistry
  • Laboratory Medicine
  • Quality Control

Background:

  • Traditional quality control materials in clinical chemistry face challenges including cost, availability, and matrix effects.
  • Hematology labs pioneered average of normals techniques due to difficulties with stable control materials.

Purpose of the Study:

  • To review the history and methods of patient-based quality control (PBQC) in clinical chemistry.
  • To discuss the integration of PBQC with existing quality control strategies.
  • To highlight the advantages of PBQC in detecting clinically significant assay biases and addressing non-commutability issues.

Main Methods:

  • Review of historical developments in quality control for clinical chemistry.
  • Summary of various patient-based quality control algorithms and their implementation.
  • Discussion on harmonizing results globally through advanced quality control.

Main Results:

  • Patient-based quality control algorithms are now feasible due to increased testing volumes and computational power.
  • PBQC can identify clinically significant assay biases missed by traditional methods.
  • Non-commutability of control materials is a growing concern addressed by PBQC.

Conclusions:

  • Patient-based quality control is a viable and increasingly necessary strategy for routine clinical chemistry.
  • Integration of PBQC with traditional methods can enhance overall laboratory quality assurance.
  • PBQC supports global harmonization of laboratory results by overcoming limitations of synthetic controls.