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Updated: Dec 20, 2025

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Central composite designed solid dispersion for dissolution enhancement of fluvastatin sodium by kneading technique
Sukhbir Singh1, Neelam Sharma1, Gurpreet Kaur1
1Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Abstract:
Aim: This research is focused on enhancing aqueous solubility and dissolution of fluvastatin sodium (FSS) through solid dispersion (FSS-SD) production using polyethylene glycol 6000 and polyvinyl pyrollidone K-30 by kneading technique. Methodology & results: Central composite design explored the influence of polyethylene glycol 6000 and polyvinyl pyrollidone K-30 on T50% and Q90. The aqueous saturation solubility of FSS (8.7 ± 1.12 μg/ml) was amplified 20-fold in FSS-SD (179 ± 4.16 μg/ml). Cumulative drug release from FSS and optimized FSS-SD were 27.49 and 87.4% within 90 min, respectively. Conclusion: FSS-SD production using kneading technique offers great prospective in maximizing FSS's solubility and dissolution.
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