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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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ncRI: a manually curated database for experimentally validated non-coding RNAs in inflammation.

Shuyuan Wang1, Shunheng Zhou2, Haizhou Liu2

  • 1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.

BMC Genomics
|June 4, 2020
PubMed
Summary
This summary is machine-generated.

This study introduces ncRI, a database of non-coding RNAs (ncRNAs) involved in inflammatory diseases. It offers a comprehensive resource for researchers studying ncRNAs and their role in immunotherapy.

Keywords:
DatabaseImmune factorInflammatory diseaseInflammatory processNon-coding RNA

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Area of Science:

  • Immunology
  • Genetics
  • Bioinformatics

Background:

  • Inflammation is a key factor in infectious diseases and cancer.
  • Non-coding RNAs (ncRNAs), including miRNAs and lncRNAs, regulate immune and inflammatory responses.
  • ncRNAs are crucial in inflammatory diseases and immunotherapy.

Purpose of the Study:

  • To create a centralized database of experimentally verified ncRNAs in inflammatory diseases.
  • To provide a comprehensive resource for researchers in the field of ncRNA and inflammation.

Main Methods:

  • Data collection from published articles.
  • Curation of information on ncRNA name, associated inflammatory diseases, mechanisms, and experimental validation.
  • Inclusion of details on experimental techniques, samples, expression patterns, and references.

Main Results:

  • The ncRI database contains 11,166 entries, including 1976 miRNAs, 1377 lncRNAs, and 107 other ncRNAs.
  • Data spans across human, mouse, and rat species, compiled from over 2000 articles.
  • Information includes ncRNA details, disease associations, experimental methods, and expression patterns.

Conclusions:

  • The ncRI database serves as a comprehensive and credible repository for ncRNAs in inflammatory diseases.
  • This resource will aid research in immunotherapy and understanding ncRNA functions in inflammation.
  • The ncRI database is freely accessible online.