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Published on: March 8, 2019
Carboxylic acid mediated antimicrobial activity of silicone elastomers
Andreas Köllnberger1, Rainer Schrader1, Christoph A Briehn2
1Wacker Chemie AG, Burghausen, Germany.
Abstract:
Due to their high biocompatibility silicone elastomers are the material of choice in many sensitive health care applications. However, the inherent hydrophobicity of the polymer makes silicones more susceptible to spontaneous protein adsorption and subsequent biofilm formation than more hydrophilic abiotic materials. Hence, the development of antimicrobial silicone elastomers could help to reduce potential biofilm-associated infections when using silicone based medical devices. In this study, we describe carboxylic-acid-modified silicone elastomers that are biocompatible and exhibit a specific antimicrobial activity against clinically relevant pathogens even after being stored in common packaging materials.
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