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Updated: Dec 19, 2025

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
09:38

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Published on: June 26, 2019

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Osimertinib Called "Home Run" for EGFR-Mutant NSCLC

    Cancer Discovery
    |June 4, 2020
    PubMed

    Insights

    Adjuvant osimertinib significantly improves outcomes for patients with EGFR-mutant non-small cell lung cancer. The ADAURA trial showed a dramatic increase in disease-free survival, leading to early unblinding.

    Area of Science:

    • Oncology
    • Pharmacology

    Background:

    • Non-small cell lung cancer (NSCLC) with EGFR mutations presents a target for specific therapies.
    • Adjuvant therapy aims to eliminate residual cancer cells after primary treatment.

    Discussion:

    • The ADAURA trial investigated the efficacy of osimertinib as adjuvant treatment for early-stage NSCLC with EGFR mutations.
    • Early unblinding of the trial was prompted by overwhelmingly positive results.

    Key Insights:

    • Adjuvant osimertinib demonstrated a significant improvement in disease-free survival in patients with stage II-IIIA EGFR-mutant NSCLC.
    • 90% of patients receiving osimertinib remained alive and cancer-free at 2 years, compared to 44% in the placebo group.

    Outlook:

    • Osimertinib is poised to become a new standard of care for adjuvant treatment in this patient population.
    • These findings underscore the importance of targeted therapies in early-stage NSCLC.

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