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Updated: Dec 19, 2025

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma
Published on: June 2, 2023
Anti-infectious and Anti-tumor Activities of β-glucans
Vaclav Vetvicka1, Jana Vetvickova2
1Department of Pathology, University of Louisville, Louisville, KY, U.S.A. Vaclav.vetvicka@louisville.edu.
Background/Aim:
The aim of this study was to directly compare the anti-infectious and anti-cancer effects of five commercially available glucans.
Materials And Methods:
We used five different glucans isolated from algae, yeast, bacteria, oat, and mushroom. We compared their effects on the stimulation of phagocytosis of blood cells, on the secretion of IL-2, and on the inhibition of melanoma and breast and lung cancers. In addition, we evaluated the effects of glucan supplementation on two experimental models of infection.
Results:
Most of the tested glucans stimulated phagocytosis and IL-2 secretion, reduced cancer growth, and ameliorated some effects of experimental infections.
Conclusion:
Glucans can produce significant pleiotropic effects, but the activity varies among individual samples.
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