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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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Related Experiment Video

Updated: Dec 19, 2025

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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Melanoma Risk Estimation Based on Objective Measures as a Complement to Self-Assessment.

Adam Carlsson1, Magnus Falk2

  • 1Department of Health, Medicine and Caring Sciences Linköping University, Linköping, Sweden.

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|June 4, 2020
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Summary

Objective measures like UV sensitivity phototesting and nevi count improve skin cancer risk assessment. This personalized risk score and advice led to increased sun protection behaviors in high-risk individuals.

Keywords:
Malignant melanomaquestionnairesun habitstailored adviceultraviolet radiation

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Area of Science:

  • Dermatology
  • Public Health
  • Medical Diagnostics

Background:

  • Online skin cancer risk self-tests often rely on subjective measures, limiting their accuracy.
  • Self-estimated skin sensitivity to sun exposure is a key factor affecting reliability.

Purpose of the Study:

  • To evaluate the contribution of objective variables (UV sensitivity phototesting, nevi count) to a comprehensive skin cancer risk score.
  • To determine if a risk score based on objective measures can change sun protection behavior.

Main Methods:

  • 70 university students completed the Sun Exposure and Protection Index (SEPI) questionnaire.
  • Skin UV sensitivity was assessed via self-estimation and objective phototesting; nevi counts were self-performed and observer-performed.
  • A cumulative skin cancer risk score was calculated using self-assessed and objective data.

Main Results:

  • Good correlation was found for nevi counts, but poor agreement for UV sensitivity between self-assessment and objective measures.
  • The risk score based on objective measures showed no systematic difference from self-assessed scores.
  • High-risk individuals demonstrated a significant decrease in SEPI scores post-intervention.

Conclusions:

  • Objective assessment of nevi count and UV sensitivity significantly enhances individual skin cancer risk evaluation.
  • Tailored sun protection advice based on objective risk assessment can promote behavioral changes.