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Association Between Structure-function Characteristics and Visual Field Outcomes in Glaucoma Subjects With

Aistė Kadziauskienė1,2, Jacqueline Chua3,4, Mani Baskaran3,4

  • 1Clinic of Ears, Nose, Throat and Eye Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University.

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Summary
This summary is machine-generated.

Preoperative nerve fiber layer thickness, baseline visual field, and glaucoma severity predict post-trabeculectomy visual field outcomes. The structure-function relationship shows potential for predicting visual field progression after glaucoma surgery.

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Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Surgical Outcomes

Background:

  • Trabeculectomy is a common surgical procedure for glaucoma.
  • Predicting visual field (VF) outcomes after trabeculectomy is crucial for patient management.
  • The relationship between ocular structure and visual function is complex and influences disease progression.

Purpose of the Study:

  • To determine if the preoperative structure-function relationship can predict visual outcomes one year after trabeculectomy.
  • To identify key preoperative factors associated with improved visual field outcomes post-surgery.

Main Methods:

  • A study included 91 eyes from 87 participants who underwent trabeculectomy.
  • Optical coherence tomography and visual field assessments were performed preoperatively and one year postoperatively.
  • Statistical analyses included linear mixed-model and multivariate analyses to assess structure-function associations and predict outcomes.

Main Results:

  • A positive preoperative retinal nerve fiber layer thickness deviation from the structure-function model significantly predicted improved postoperative VF outcomes.
  • Baseline visual field mean depth and the presence of severe glaucoma were also significant predictors of postoperative VF outcomes.
  • Intraocular pressure showed a positive association with improved VF outcomes in univariate analysis.

Conclusions:

  • Preoperative characteristics derived from the structure-function relationship are strongly associated with postoperative visual field outcomes.
  • The structure-function relationship holds potential as a tool for predicting visual field progression after trabeculectomy.
  • These findings can aid in personalized risk stratification and management strategies for glaucoma patients undergoing surgery.