Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Propagation of Uncertainty from Random Error00:59

Propagation of Uncertainty from Random Error

1.6K
An experiment often consists of more than a single step. In this case, measurements at each step give rise to uncertainty. Because the measurements occur in successive steps, the uncertainty in one step necessarily contributes to that in the subsequent step. As we perform statistical analysis on these types of experiments, we must learn to account for the propagation of uncertainty from one step to the next. The propagation of uncertainty depends on the type of arithmetic operation performed on...
1.6K
Propagation of Uncertainty from Systematic Error01:10

Propagation of Uncertainty from Systematic Error

1.2K
The atomic mass of an element varies due to the relative ratio of its isotopes. A sample's relative proportion of oxygen isotopes influences its average atomic mass. For instance, if we were to measure the atomic mass of oxygen from a sample, the mass would be a weighted average of the isotopic masses of oxygen in that sample. Since a single sample is not likely to perfectly reflect the true atomic mass of oxygen for all the molecules of oxygen on Earth, the mass we obtain from this...
1.2K
Confidence Coefficient01:24

Confidence Coefficient

10.1K
The confidence coefficient is also known as the confidence level or degree of confidence. It is the percent expression for the probability, 1-α, that the confidence interval contains the true population parameter assuming that the confidence interval is obtained after sufficient unbiased sampling; for example, if the CL = 90%, then in 90 out of 100 samples the interval estimate will enclose the true population parameter. Here α is the area under the curve, distributed equally under...
10.1K
Improving Translational Accuracy02:07

Improving Translational Accuracy

13.9K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
13.9K
Improving Translational Accuracy02:07

Improving Translational Accuracy

3.4K
3.4K
Neural Circuits01:25

Neural Circuits

2.5K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurement properties of the interest in health scale among community-dwelling older adults in Japan: Verification of the 12-item, 6-item, and 4-item versions of the interest in health scale.

Preventive medicine reports·2026
Same author

Continuous glucose monitoring-derived time in range is associated with changes in arterial stiffness in type 2 diabetes.

The Journal of clinical endocrinology and metabolism·2026
Same author

Balloon-occluded Alternative Infusion of Fragmented Gelatin Particles of TACE for Hepatocellular Carcinoma Refractory to Atezolizumab-Bevacizumab.

Anticancer research·2026
Same author

Mid-treatment MRI-based tumor volume reduction rate as a continuous prognostic factor after chemoradiation for cervical cancer: development and two-center internal-external validation.

Journal of radiation research·2026
Same author

Response to "Reconsidering 'photon-ineligible' status in concurrent chemo-proton therapy for stage III non-small cell lung cancer".

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

Physicochemical and functional properties of albumin fractions from barley and rye seed protein isolate.

Bioscience, biotechnology, and biochemistry·2026
Same journal

Efficacy and safety of Ensitrelvir in COVID-19 patients: a systematic review and meta-analysis with focus on viral clearance and RNA change.

European journal of clinical pharmacology·2026
Same journal

Comparing National Health Technology Assessment approaches and the new European Joint Clinical Assessment framework: The case of onco-hematological medicines.

European journal of clinical pharmacology·2026
Same journal

The efficacy of letrozole in the medical management of ectopic pregnancy: a systematic review and meta-analysis.

European journal of clinical pharmacology·2026
Same journal

Detection of intravenous drug physicochemical incompatibilities in clinical practice: e-Harvis compared to reference tools.

European journal of clinical pharmacology·2026
Same journal

Efficacy and safety of doravirine/islatravir for the treatment of HIV-1: a systematic review and meta-analysis of randomized controlled trials with GRADE assessment.

European journal of clinical pharmacology·2026
Same journal

Critical analysis of digitalis glycosides: declining use but increasing poison-center exposure cases for digitoxin.

European journal of clinical pharmacology·2026
See all related articles

Related Experiment Video

Updated: Dec 19, 2025

Decoding Natural Behavior from Neuroethological Embedding
08:00

Decoding Natural Behavior from Neuroethological Embedding

Published on: October 3, 2025

463

Borrowing external information to improve Bayesian confidence propagation neural network.

Keisuke Tada1,2, Kazushi Maruo3, Naoki Isogawa4

  • 1Biostatistics & Programming, Sanofi K.K, Tokyo Opera City Tower, 3-20-2, Nishi Shinjuku, Shinjuku-ku, Tokyo, 163-1488, Japan. Keisuke.Tada@sanofi.com.

European Journal of Clinical Pharmacology
|June 4, 2020
PubMed
Summary
This summary is machine-generated.

This study enhances the Bayesian confidence propagation neural network (BCPNN) for improved adverse drug reaction (ADR) detection. The modified BCPNN shows higher sensitivity and earlier signal detection compared to traditional methods.

Keywords:
Dynamic borrowingInformation componentPharmacovigilanceSignal detection

Related Experiment Videos

Last Updated: Dec 19, 2025

Decoding Natural Behavior from Neuroethological Embedding
08:00

Decoding Natural Behavior from Neuroethological Embedding

Published on: October 3, 2025

463

Area of Science:

  • Pharmacovigilance
  • Biostatistics
  • Machine Learning

Background:

  • Spontaneous reporting systems are crucial for drug safety surveillance.
  • Bayesian confidence propagation neural network (BCPNN) is a standard signal detection tool.
  • Existing methods may lack sensitivity in identifying potential adverse drug reactions (ADRs).

Purpose of the Study:

  • To modify the BCPNN to enhance its sensitivity for detecting potential ADRs.
  • To evaluate the performance of the modified BCPNN against the traditional approach.

Main Methods:

  • The Information Component (IC) was adjusted by incorporating data from similar drugs.
  • A simulation study was conducted to compare the proposed method with the traditional BCPNN.
  • The methods were applied to a Japanese regulatory authority's database.

Main Results:

  • The modified BCPNN demonstrated a lower false positive rate, close to the nominal 0.025.
  • Sensitivity was significantly higher for the proposed method, especially when differences in ICs ranged from 0 to 2.
  • The modified method detected known ADRs earlier in a real-world database.

Conclusions:

  • The proposed BCPNN modification offers a novel criterion for early ADR signal detection, particularly when similar drugs exhibit comparable tendencies.
  • The enhanced BCPNN shows increased sensitivity, especially with a true difference greater than 0.