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Updated: Dec 19, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

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Association between alcohol intake, mild cognitive impairment and progression to dementia: a dose-response

Yongfeng Lao1, Lijuan Hou2, Jing Li3

  • 1Second Clinical Medical College, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.

Aging Clinical and Experimental Research
|June 4, 2020
PubMed
Abstract

Insights

Excessive alcohol consumption increases the risk of progression to dementia in people with mild cognitive impairment (MCI). Even moderate drinking may elevate the risk of MCI, highlighting the need for careful alcohol intake management.

Area of Science:

  • Neuroscience
  • Public Health
  • Epidemiology

Background:

  • Mild cognitive impairment (MCI) represents a transitional stage between normal aging and dementia.
  • The specific impact of alcohol consumption on MCI development and progression to dementia remains incompletely understood.

Purpose of the Study:

  • To systematically review and synthesize existing evidence on the association between alcohol intake and the risk of developing MCI.
  • To clarify the relationship between alcohol consumption patterns and the progression to dementia in individuals already diagnosed with MCI (PDM).

Main Methods:

  • A comprehensive literature search was conducted across major databases (PubMed, EMBASE, Cochrane Library, CBM) up to October 2019.
  • Prospective cohort studies with at least three alcohol exposure levels were included.
  • Meta-analysis, including restricted cubic spline and dose-response models, was employed to quantify the risks associated with light, moderate, and heavy alcohol intake.

Main Results:

  • Analysis of six cohort studies (4244 participants) revealed a potential linear association between weekly alcohol intake and MCI risk.
  • Heavy alcohol consumption (over 14 drinks/week) was significantly linked to an increased risk of progression to dementia in people with MCI (PDM).
  • A nonlinear dose-response relationship was observed, with excessive drinking (over 16 drinks/week or 27.5 g/day) elevating PDM risk.

Conclusions:

  • A nonlinear dose-response relationship exists between alcohol intake and the risk of progression to dementia in individuals with MCI.
  • Excessive alcohol consumption is a significant risk factor for the progression of mild cognitive impairment to dementia.
Keywords:
AlcoholDementiaDose–responseMeta-analysisMild cognitive impairment

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