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Immunotropic Properties of an Experimental Synthetic Selenium-Organic Compound
O V Yur'eva1, V I Dubrovina2, V A Potapov3
1Irkutsk Antiplague Research Institute, Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Irkutsk, Russia.
Bulletin of Experimental Biology and Medicine
|June 4, 2020
Summary
This study investigated a synthetic selenium compound, 974zh, revealing its ability to enhance immune cell activity. The compound boosted resistance against the plague pathogen, Yersinia pestis, by increasing immune response.
Area of Science:
- Immunology
- Medicinal Chemistry
- Pharmacology
Background:
- The immune system's response to pathogens is crucial for host defense.
- Selenium-organic compounds are explored for their potential immunomodulatory effects.
- Understanding novel compounds' impact on immune cell proliferation is vital.
Purpose of the Study:
- To evaluate the immunotropic properties of the synthetic selenium-organic preparation 2,6-dipyridinium-9-selenabicyclo[3.3.1]nonyl dibromide (974zh).
- To assess the effect of 974zh on the cAMP/cGMP ratio in immunocompetent organs.
- To determine the influence of 974zh on immune response and resistance to Yersinia pestis.
Main Methods:
- Administration of synthetic selenium-organic preparation 974zh to experimental animals.
- Measurement of cAMP/cGMP ratio in thymus and spleen cells.
- Assessment of immune response intensity and resistance to Yersinia pestis EV.
Main Results:
- The preparation 974zh reduced the cAMP/cGMP ratio, indicating enhanced cellular proliferative activity.
- Immunocompetent organ cells (thymus and spleen) showed increased proliferative activity.
- 974zh significantly intensified the immune response to Yersinia pestis EV.
Conclusions:
- The synthetic selenium-organic preparation 974zh exhibits significant immunotropic properties.
- 974zh enhances cellular proliferation in immunocompetent organs.
- The compound increases resistance to Yersinia pestis by boosting the immune response.
