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Updated: Dec 19, 2025

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells
Published on: July 29, 2015
Comparative Analysis of the Paracrine Action of Neuronal and Glial Progenitor Cells Derived from Induced Human
D I Salikhova1,2, G E Leonov3, T B Bukharova3
1N. P. Bochkov Research Center for Medical Genetics, Moscow, Russia. diana_salikhova@bk.ru.
Abstract:
We performed comparative analysis of paracrine activity of neuronal and glial progenitors derived from induced pluripotent stem cells under conditions of hypoxia modeled by addition of cobalt dichloride. Neuronal and glial progenitors produced neuroprotective and neurotrophic effects on SHSY-5Y neuroblastoma cells in co-culture during the post-hypoxic recovery and reduced the number of apoptotic and necrotic cells. Moreover, they produced a neurotrophic effect and promote the formation and growth of neurites in neuroblastoma cells. The paracrine effect of glial progenitors was more pronounced, which can be explained by more intensive expression and secretion of neurotrophic factors in these cells.
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