Related Experiment Video

Updated: Dec 19, 2025

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

Relationship of thyroid dysfunction with cardiovascular diseases: updated review on heart failure progression

Adel Abdel-Moneim¹, Asmaa M Gaber², Sherouk Gouda³

¹Molecular Physiology Division, Faculty of Science, Beni-Suef University, Salah Salem St., Beni Suef, 62511,, Egypt. adel_men2020@yahoo.com.

Hormones (Athens, Greece)

|June 4, 2020

Insights

Thyroid dysfunction significantly impacts heart function and can lead to heart failure (HF). Understanding these effects is crucial for managing cardiovascular disease and exploring thyroid hormone replacement therapy for better patient outcomes.

Area of Science:

Cardiology
Endocrinology
Molecular Biology

Background:

Heart disease is a leading global cause of death.
Heart failure (HF) arises from impaired ventricular function.
Thyroid hormones influence cardiovascular homeostasis through genomic and non-genomic pathways.

Purpose of the Study:

To review the impact of thyroid hormone dysfunction on heart failure pathophysiology.
To highlight the role of thyroid hormones in cardiovascular events.
To discuss potential therapeutic implications of thyroid hormone replacement.

Main Methods:

Review of accumulated evidence on thyroid hormones and cardiovascular events.
Analysis of genomic and non-genomic actions of thyroid hormones in cardiomyocytes.
Examination of clinical data on thyroid dysfunction and heart failure.

Main Results:

Thyroid dysfunction (hypothyroidism, hyperthyroidism, low triiodothyronine syndrome) adversely affects cardiac function.
Thyroid hormone levels influence myocardial contractility, blood pressure, heart rate, and ejection fraction.
Thyroid hormone replacement therapy shows potential in reducing cardiovascular events in hypothyroid patients.

Conclusions:

Thyroid hormone dysfunction is a significant contributor to the development and progression of heart failure.
Maintaining thyroid hormone balance is essential for cardiac homeostasis.
Further research into thyroid hormone's role in cardiovascular health may reveal new therapeutic strategies.

Read full analysis

Abstract:

Heart disease remains the leading cause of death globally. Heart failure (HF) is a clinical syndrome that results from impairment of the ability of the ventricle to fill with or eject blood. Over the past two decades, accumulated evidence has revealed the contribution of thyroid hormones to cardiovascular (CV) events, exerting their action through genomic and non-genomic pathways within the cardiomyocytes. The pivotal role of thyroid hormones in maintaining cardiac homeostasis has been observed in previous investigations which suggest that the CV system is adversely impacted by fluctuations in thyroid hormone levels, such as those that occur in hypothyroidism, hyperthyroidism, and low triiodothyronine syndrome (LT₃S). Thyroid dysfunction has direct effects on myocardial contractility, systolic and diastolic blood pressure, heart mass, heart rate, ejection fraction, and heart output, which may ultimately lead to HF. Recent clinical data have shown that thyroid hormone replacement therapy for hypothyroid patients appears to provide the potential for reducing CV events. Therefore, this review aims to address the impact of thyroid hormone dysfunction on pathophysiological mechanisms contributing to the development and progression of HF.

Keywords:

Heart failure Hyperthyroidism Hypothyroidism Thyroid hormone

More Related Videos

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

Related Concept Videos

Heart Failure I: Introduction

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...

Pathophysiology of Heart Failure

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...

Heart Failure IV: Classification and Diagnostic Evaluation

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...

Heart Failure II: Pathophysiology

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...

Functions of Thyroid Hormones

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...

Heart Failure VII: Nursing Interventions

Heart Failure VII: Nursing Interventions

The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...

Articles linked to this work by shared authors, journal, and citation graph.

Structure-Based Discovery of Fumiquinazolines as Skp2-Cks1 Protein-Protein Interaction Disruptors: Mechanistic Computational Insights and Experimental Validation.

ChemMedChem·2026

Structure-based discovery of diphenylpyrazines as disruptors of the Skp2-Cks1 protein-protein interaction: computational insights and biochemical validation.

Journal of computer-aided molecular design·2026

Breaking the Myb-KIX Alliance: Structure-Guided Discovery of Biaryl Hydroxy-Naphthamides as Disruptors of the c-Myb-CBP/p300 KIX Protein-Protein Interaction.

Archiv der Pharmazie·2026

Structure-guided identification of 2-arylbenzothiazoles as disruptors of the oncogenic MTDH-SND1 protein-protein interaction.

Archives of biochemistry and biophysics·2026

Diaryl terephthalamides as small-molecule disruptors of the c-Myb-CBP/p300 KIX protein-protein interaction: Mechanistic insights and biochemical validation.

Biochemical and biophysical research communications·2026

Structure-Based Discovery of N-Aryl-N'-Heteroaryl Ureas as Disruptors of the Oncogenic MTDH-SND1 Protein-Protein Interaction: In Silico Insights and Biochemical Validation.

Archiv der Pharmazie·2026

See all related articles