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Clinical trials for coronavirus disease 2019: What is being evaluated and what is not

Yaseen M Arabi1,2,3, Ayed Asseri4, Steve Webb5

  • 1Intensive Care Department, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

Annals of Thoracic Medicine
|June 4, 2020
PubMed

Insights

The global research response to coronavirus disease 2019 (COVID-19) has been rapid, with numerous studies and clinical trials initiated to understand and treat the novel virus. This swift action aims to accelerate the development of effective therapeutic options.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Clinical Research

Background:

  • The emergence of coronavirus disease 2019 (COVID-19) in late 2019 has led to a global health crisis.
  • As of March 18, 2020, over 204,610 cases were reported worldwide.
  • The rapid spread necessitated an urgent and comprehensive research response.

Purpose of the Study:

  • To characterize the novel coronavirus disease (COVID-19).
  • To evaluate potential therapeutic interventions for COVID-19.
  • To document the global research and clinical trial landscape for COVID-19.

Main Methods:

  • Systematic review of registered clinical trials.
  • Analysis of global case reporting data.
  • Literature search for ongoing research efforts.

Main Results:

  • Over 382 studies addressing COVID-19 were registered in clinical trial databases by March 12, 2020.
  • More than 80 of these registered studies were randomized controlled trials.
  • Significant global research activity is focused on understanding and treating COVID-19.

Conclusions:

  • The scientific community has mobilized rapidly to address the COVID-19 pandemic.
  • A substantial number of clinical trials are underway to find effective treatments.
  • Ongoing research is crucial for managing the current outbreak and future preparedness.
Keywords:
Clinical trialscoronavirus disease 2019outbreak response

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