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Avenanthramide C suppresses hypoxia-induced cyclooxygenase-2 expression through sirtuin1 activation in non-small-cell

Wonchung Lim1, Chounghun Kang2

  • 1Department of Sports Medicine, College of Health Science, Cheongju University, Cheongju, South Korea.

Animal Cells and Systems
|June 4, 2020
PubMed

Insights

Avenanthramide C (AVC) from oats reduces inflammation. This study shows AVC inhibits hypoxia-induced cyclooxygenase-2 (COX-2) via SIRT1 activation, suggesting benefits for lung inflammation.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Avenanthramide C (AVC), a compound found in oats, exhibits anti-inflammatory properties.
  • Hypoxia can induce cyclooxygenase-2 (COX-2) expression, contributing to inflammation.
  • Understanding the molecular mechanisms regulating COX-2 under hypoxia is crucial for developing anti-inflammatory strategies.

Purpose of the Study:

  • To investigate the effect of Avenanthramide C (AVC) on hypoxia-induced cyclooxygenase-2 (COX-2) expression in A549 lung cells.
  • To elucidate the role of SIRT1 in mediating the effects of AVC on COX-2 expression.

Main Methods:

  • A549 cells were exposed to hypoxia.
  • The effects of AVC on COX-2 protein levels and promoter activity were assessed.
  • The involvement of SIRT1 was examined using a SIRT1 inhibitor.

Main Results:

  • AVC suppressed the hypoxia-induced increase in COX-2 protein levels.
  • AVC reduced hypoxia-induced COX-2 promoter activity.
  • The inhibitory effects of AVC on COX-2 were reversed by a SIRT1 inhibitor, indicating SIRT1 mediation.

Conclusions:

  • Avenanthramide C inhibits hypoxia-induced COX-2 expression through SIRT1 activation.
  • AVC demonstrates potential as a therapeutic agent for preventing lung inflammation associated with hypoxia.
Keywords:
Avenanthramide CSIRT1cyclooxygenase-2hypoxia

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