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Pediatric Toxicoepidemiology of Tramadol Intoxication in Iran: A 5-year Cross-Sectional Study

Mohaddeseh Hedayati Goudarzi1, Nastaran Eizadi-Mood2, Marjan Mansourian3

  • 1Pharmacy Students' Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.

Journal of Research in Pharmacy Practice
|June 4, 2020
PubMed

Insights

Tramadol poisoning in children is decreasing, often intentional in young children and accidental in adolescents. Safer packaging and education are recommended to prevent pediatric tramadol poisonings.

Area of Science:

  • Toxicology
  • Pediatrics
  • Epidemiology

Background:

  • Tramadol poisoning is a significant concern in pediatric populations.
  • Understanding toxicoepidemiological indicators is crucial for effective management and prevention.

Purpose of the Study:

  • To identify toxicoepidemiological indicators of tramadol poisoning in children.
  • To examine the relationship between these indicators and treatment outcomes.

Main Methods:

  • Retrospective data collection from a cross-sectional study.
  • Inclusion of pediatric patients (under 18) admitted for tramadol poisoning between 2010-2015.
  • Analysis of demographic data, ingested dose, clinical signs, co-ingestions, and treatment outcomes.

Main Results:

  • 189 pediatric patients were analyzed; 53.4% were male, with a mean age of 16.66 years.
  • Intentional intoxications accounted for 93.1% of cases; 42.9% involved co-ingestions.
  • Common treatments included activated charcoal, gastric lavage, and oxygen therapy; naloxone was administered in 11.6% of cases.

Conclusions:

  • Tramadol poisoning in children shows a decreasing trend, with intentional poisonings more common in younger children and accidental in adolescents.
  • Recommendations include enhanced emotional intelligence education for young adults and improved child-resistant packaging.
  • Preventive strategies are essential to reduce the incidence of pediatric tramadol poisoning.
Abstract

Keywords:
Acute poisoningIranTramadolchildrenpediatric toxicoepidemiology

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