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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

234
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
234
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

217
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
217
Tissue Transplantation01:24

Tissue Transplantation

791
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
791
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

250
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
250

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Related Experiment Video

Updated: Dec 19, 2025

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
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Essential updates 2018/2019: Liver transplantation.

Masahiro Ohira1,2, Naoki Tanimine1, Tsuyoshi Kobayashi1

  • 1Department of Gastroenterological and Transplant Surgery Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan.

Annals of Gastroenterological Surgery
|June 4, 2020
PubMed
Summary

Direct-acting antiviral agents (DAAs) offer near-100% cure rates for hepatitis C virus (HCV) in liver transplant (LT) patients. Research also explores expanded criteria for liver cancer patients and the impact of donor-specific antibodies on LT outcomes.

Keywords:
hepatitis C virushepatocellular carcinomaimmunosuppressionliver graftliver transplantation

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Area of Science:

  • Hepatology and Transplant Surgery
  • Immunology and Infectious Diseases

Background:

  • Hepatitis C virus (HCV) infection poses a significant challenge in liver transplantation (LT).
  • Hepatocellular carcinoma (HCC) management and donor-specific antibodies (DSAs) are critical areas of ongoing research in LT.

Purpose of the Study:

  • To review recent advancements in liver transplantation.
  • To discuss the management of HCV recurrence, immunosuppression optimization, and expanded donor criteria.

Main Methods:

  • Review of current literature on direct-acting antiviral agents (DAAs) for HCV in LT.
  • Analysis of studies on expanded criteria for hepatocellular carcinoma (HCC) in LT candidates.
  • Examination of research on donor-specific antibodies (DSAs) and their impact on LT outcomes.

Main Results:

  • DAAs demonstrate high efficacy and tolerability for curing HCV in LT recipients.
  • Expanded criteria beyond Milan criteria show promising results for HCC patients undergoing LT.
  • The role of DSAs in LT rejection and graft survival requires further investigation.

Conclusions:

  • DAA therapy represents a major breakthrough for HCV management in LT.
  • Refined criteria for HCC and understanding DSAs are crucial for improving LT success rates.