Ser49Gly Beta1-Adrenergic Receptor Genetic Polymorphism as a Death Predictor in Brazilian Patients with Heart Failure

Felipe Neves de Albuquerque1,2, Andrea Araujo Brandão1, Dayse Aparecida Silva3

  • 1Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

Insights

The Ser49Gly beta1-adrenergic receptor genetic polymorphism (ADBR1-GP-Ser49Gly) is linked to better outcomes in Brazilian heart failure patients. The Gly allele offers protection against mortality, reducing death risk by 63%.

Area of Science:

  • Cardiology
  • Genetics
  • Pharmacogenomics

Background:

  • The prognostic role of the Ser49Gly beta1-adrenergic receptor genetic polymorphism (ADBR1-GP-Ser49Gly) in heart failure (HF) remains unclear in Brazil.
  • Understanding genetic influences on HF outcomes is crucial for personalized medicine.

Purpose of the Study:

  • To investigate the association between ADBR1-GP-Ser49Gly variants and clinical outcomes in patients with heart failure with reduced ejection fraction (HFrEF).
  • To determine if the Gly allele confers a protective effect against mortality in this population.

Main Methods:

  • Secondary analysis of medical records from 178 HFrEF patients.
  • Genotyping of ADBR1-GP-Ser49Gly variants (Ser-Ser, Ser-Gly, Gly-Gly).
  • Evaluation of associations between genotypes and clinical outcomes, including mortality and NYHA functional class, over a 6.7-year follow-up.

Main Results:

  • The Gly-Gly genotype was associated with a less advanced NYHA functional class at follow-up (p = 0.014).
  • A significant association was found between mortality and ADBR1-GP-Ser49Gly (p = 0.026).
  • Patients with Ser-Gly or Gly-Gly genotypes had lower mortality rates compared to Ser-Ser.
  • The Gly allele demonstrated an independent protective effect, reducing the risk of death by 63% (p = 0.03; OR 0.37).

Conclusions:

  • The presence of the β1-AR-GP Gly-Gly genotype is associated with better clinical outcomes, including improved NYHA functional class.
  • The Gly allele of ADBR1-GP-Ser49Gly acts as a significant predictor of lower mortality risk in HFrEF patients, independent of other factors.

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