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Human fusariosis: An emerging infection that is difficult to treat

Bruna Gerardon Batista1, Magda Antunes de Chaves2, Paula Reginatto1

  • 1Programa de Pós-Graduação Stricto Sensu em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.

Revista Da Sociedade Brasileira De Medicina Tropical
|June 4, 2020
PubMed

Insights

Fusarium species cause emerging fungal infections called fusariosis. Limited treatments exist, but drug combinations may combat antifungal resistance and invasive fusariosis.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Fusarium species are increasingly recognized as emerging pathogens causing a range of infections, collectively known as fusariosis.
  • Fusarium solani and Fusarium oxysporum are the most frequently implicated species globally.
  • Invasive fusariosis presents a significant clinical challenge due to limited therapeutic options.

Purpose of the Study:

  • To review the characteristics, clinical management, incidence, and emergence of fusariosis.
  • To highlight the challenges in treating invasive fusariosis.
  • To explore potential strategies for overcoming antifungal resistance.

Main Methods:

  • Systematic review of articles published between 2005 and 2018.
  • Analysis of case reports and clinical data on Fusarium infections.
  • Evaluation of therapeutic strategies and antifungal resistance patterns.

Main Results:

  • Fusariosis is an emerging global health concern, with a notable increase in invasive cases reported between 2005 and 2018.
  • Fusarium solani and F. oxysporum are the predominant species involved in human infections.
  • Intrinsic antifungal resistance limits treatment options for invasive fusariosis.

Conclusions:

  • The rise in invasive fusariosis cases underscores its emergence as a significant threat.
  • Drug combinations represent a promising alternative to address systemic antifungal resistance.
  • Further research into novel therapeutic strategies is crucial for managing fusariosis effectively.

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