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Related Experiment Video

Updated: Dec 19, 2025

Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection
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Synchronization in reaction-diffusion systems with multiple pacemakers.

F E Nolet1, J Rombouts1, L Gelens1

  • 1Laboratory of Dynamics in Biological Systems, Department of Cellular and Molecular Medicine, University of Leuven, 3000 Leuven, Belgium.

Chaos (Woodbury, N.Y.)
|June 4, 2020
PubMed
Summary
This summary is machine-generated.

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Multiple pacemakers in oscillatory systems compete, influencing wave propagation and synchronization. Their size and frequency determine how the system synchronizes, similar to coupled oscillators.

Area of Science:

  • Complex Systems
  • Nonlinear Dynamics
  • Mathematical Biology

Background:

  • Spatially extended oscillatory systems can synchronize through entrainment by pacemakers.
  • Pacemakers are regions with higher oscillation frequencies that drive synchronization via wave propagation.
  • Real-world systems often feature multiple competing pacemakers.

Purpose of the Study:

  • To numerically analyze how pacemaker properties affect wave propagation and synchronization in oscillatory media.
  • To investigate the impact of pacemaker size and intrinsic frequency on synchronization.
  • To study synchronization in systems with pacemakers embedded in a passive medium.

Main Methods:

  • Detailed numerical analysis of spatially extended oscillatory systems.

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  • Simulation of wave propagation originating from pacemakers.
  • Examination of synchronization phenomena under varying pacemaker characteristics and coupling strengths.
  • Main Results:

    • Pacemaker size and intrinsic frequency significantly influence the synchronization properties of the medium.
    • Synchronization can occur in passive media if pacemaker coupling (distance and diffusion) is sufficiently strong.
    • The transition to synchronization in passive media resembles that of discrete coupled oscillator systems.

    Conclusions:

    • The properties of competing pacemakers are critical determinants of wave dynamics and overall system synchronization.
    • Synchronization in passive media is achievable through sufficient coupling, highlighting the role of network structure.
    • Findings provide insights into synchronization mechanisms in diverse spatially extended systems.