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SARS-CoV-2: A comprehensive review from pathogenicity of the virus to clinical consequences

Melika Lotfi1,2, Nima Rezaei3,4,5

  • 1Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

Journal of Medical Virology
|June 4, 2020
PubMed

Insights

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a global health crisis. This review summarizes current knowledge on SARS-CoV-2 characteristics, pathogenesis, and diagnostics to aid control efforts.

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, presents a significant global health challenge.
  • High contagion rates and diverse clinical outcomes necessitate a thorough understanding of the virus.
  • Limited knowledge persists despite extensive scientific and clinical efforts.

Purpose of the Study:

  • To consolidate and present the most recent data on SARS-CoV-2.
  • To provide a comprehensive overview of the virus's characteristics and pathogenesis.
  • To detail clinical manifestations and diagnostic methodologies for COVID-19.

Main Methods:

  • Literature review of recent scientific and clinical data.
  • Synthesis of information on SARS-CoV-2 properties.
  • Compilation of data on disease progression and detection.

Main Results:

  • Detailed characteristics of SARS-CoV-2.
  • Insights into the pathogenesis of COVID-19.
  • Overview of clinical presentations and diagnostic approaches.

Conclusions:

  • Understanding SARS-CoV-2 characteristics, pathogenesis, and clinical aspects is crucial.
  • Effective preventive strategies require up-to-date knowledge.
  • This review serves as a consolidated resource for current information on SARS-CoV-2.
Keywords:
2019-nCoVCOVID-19SARS-CoV-2clinical manifestationsvirulence

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