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Microbiota and cardiovascular disease risk: A scoping review
Federico Scarmozzino1, Andrea Poli2, Francesco Visioli3
1Department of Molecular Medicine, University of Padova, Italy.
Pharmacological Research
|June 4, 2020
Summary
The gut and oral microbiota influence cardiovascular risk by altering food compounds and producing metabolites. Future cardio-prevention strategies include inhibiting harmful microbial molecules and using probiotics and prebiotics.
Area of Science:
- Microbiology
- Cardiovascular Science
- Nutritional Science
Background:
- Emerging research highlights the significant role of oral and intestinal microbiota in cardiovascular risk.
- The relationship between diet and microbiota is bidirectional, impacting health through metabolite production.
Purpose of the Study:
- To review current evidence on microbiota-cardiovascular risk interactions.
- To explore future cardio-preventive strategies targeting the microbiota.
Main Methods:
- Scoping review of scientific literature.
- Focus on oral and intestinal microbiota research.
- Analysis of microbiota-food interactions and metabolite effects.
Main Results:
- Convincing evidence supports microbiota's influence on cardiovascular risk.
- Microbiota can modify food compounds, leading to atherogenic or protective effects.
- Specific bacterial strains and prebiotics can directly impact atherogenesis.
Conclusions:
- Targeting microbiota-derived molecules offers a promising cardio-preventive approach.
- Personalized diets and supplements based on metabotype screening are future possibilities.
- Microbiota modulation using pro- and prebiotics presents a therapeutic avenue.
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