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Induction of programmed necrosis: A novel anti-cancer strategy for natural compounds

Jie Yu1, Bingling Zhong1, Qingwen Xiao1

  • 1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.

Pharmacology & Therapeutics
|June 4, 2020
PubMed

Insights

Programmed necrosis, including novel forms like noptosis, offers new anti-cancer drug strategies. Natural compounds can induce these cell death pathways, providing leads for cancer treatment development.

Area of Science:

  • Cellular biology
  • Molecular mechanisms of cell death
  • Drug discovery

Background:

  • Cell death is crucial for development and disease, with necrosis traditionally viewed as accidental.
  • Recent research reveals programmed forms of necrosis (e.g., necroptosis, ferroptosis, pyroptosis) with distinct pathways.
  • Understanding programmed necrosis offers potential therapeutic avenues, particularly for cancer treatment.

Purpose of the Study:

  • To review recent advancements in programmed necrosis.
  • To highlight natural compounds that induce programmed necrosis.
  • To discuss noptosis, a novel NAD(P)H: quinone oxidoreductase 1-dependent programmed necrosis.

Main Methods:

  • Literature review of programmed necrosis.
  • Identification of natural compound inducers.
  • Discussion of anti-cancer strategies involving programmed necrosis.

Main Results:

  • Several types of programmed necrosis have been identified, including necroptosis, ferroptosis, and pyroptosis.
  • Natural compounds can effectively induce programmed cell death pathways.
  • Noptosis, a novel programmed necrosis, is dependent on oxidative stress from NAD(P)H: quinone oxidoreductase 1.

Conclusions:

  • Programmed necrosis presents promising targets for anti-cancer drug development.
  • Natural compounds are valuable sources for discovering inducers of programmed necrosis.
  • Further research is needed to clarify biomarkers, signaling, and pathophysiological roles of programmed necrosis.
Keywords:
CancerNatural compoundsProgrammed necrosis

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