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Clinical features and short-term outcomes of elderly patients with COVID-19

Ping Li1, Lulu Chen1, Zheming Liu1

  • 1Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|June 4, 2020
PubMed

Insights

Elderly patients with Coronavirus Disease 2019 (COVID-19) face higher mortality risks. Key factors predicting in-hospital death include dyspnea, older age, neutrophilia, and elevated cardiac troponin I levels.

Area of Science:

  • Gerontology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • The Coronavirus Disease 2019 (COVID-19) pandemic poses a significant global health challenge.
  • Elderly individuals represent a vulnerable population with potentially higher risks associated with COVID-19 infection.

Purpose of the Study:

  • To investigate the clinical characteristics and risk factors associated with in-hospital mortality in elderly patients diagnosed with COVID-19.
  • To identify predictors of mortality in this specific demographic to inform clinical management.

Main Methods:

  • A retrospective study included 204 elderly patients (≥60 years) with confirmed COVID-19.
  • Data collected included demographics, comorbidities, and clinical outcomes, with in-hospital death as the primary endpoint.
  • Multivariate analysis was employed to identify independent predictors of mortality.

Main Results:

  • Common comorbidities in the study cohort included hypertension, diabetes, cardiovascular disease, and chronic obstructive pulmonary disease (COPD).
  • Of the 204 patients, 76 (37.3%) died during hospitalization.
  • Independent predictors of in-hospital death were identified as dyspnea (HR 2.2), older age (HR 1.1), neutrophilia (HR 4.4), and elevated ultrasensitive cardiac troponin I (HR 3.9).

Conclusions:

  • While overall COVID-19 mortality may be relatively low, elderly patients experience significantly higher mortality rates.
  • Early diagnosis and prompt supportive care are crucial for improving outcomes in elderly COVID-19 patients.
  • Identifying high-risk individuals through clinical and laboratory markers can aid in targeted interventions.
Abstract

Keywords:
Clinical featuresCoronavirus disease 2019 (COVID-19)ElderlyShort-term outcomes

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