Related Experiment Video

Updated: Dec 19, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

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High Blood Pressure Is Associated with Tubulointerstitial Damage along with Glomerular Damage in Glomerulonephritis.

Claudio Bazzi1, Teresa M Seccia2, Pietro Napodano3

  • 1D'Amico Foundation for Renal Disease Research, 20145 Milan, Italy.

Journal of Clinical Medicine
|June 5, 2020
PubMed

Insights

Hypertension worsens kidney damage in glomerulonephritis (GN). This study found that high blood pressure is linked to more severe tubulointerstitial damage (TID) in GN patients, independent of proteinuria.

Area of Science:

  • Nephrology
  • Pathology

Background:

  • Arterial hypertension is a known driver of chronic kidney disease (CKD) progression.
  • The specific impact of hypertension on tubulointerstitial damage (TID) within glomerulonephritis (GN) requires further clarification.

Purpose of the Study:

  • To determine if TID is associated with glomerular damage in GN.
  • To investigate if hypertensive GN patients exhibit more severe tubulointerstitial damage.

Main Methods:

  • Retrospective analysis of 448 patients with biopsy-diagnosed primary GN, lupus nephritis (LN), or nephroangiosclerosis (NAS).
  • Microscopic examination of at least six glomeruli per biopsy using light and immunofluorescence microscopy.
  • Assessment of global glomerulosclerosis (GGS%), TID, and arteriolar hyalinosis (AH) as CKD severity markers.

Main Results:

  • Hypertension was present in 52% of patients; 88.9% of NAS patients were hypertensive.
  • Hypertensive GN patients showed greater glomerular and tubular damage than normotensive patients, irrespective of proteinuria levels.
  • Both hypertension and global glomerulosclerosis (GGS%) were significantly associated with increased TID in GN.

Conclusions:

  • In glomerulonephritis patients, high blood pressure contributes to both glomerular and tubulointerstitial damage.
  • The severity of tubulointerstitial damage in GN is associated with hypertension.

Keywords:
glomerularhypertensionkidneyproteinuriatubulointerstitial damage

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