Carbon Nanomaterials for Sorption of ⁶⁸Ga for Potential Using in Positron Emission Tomography

In present work, carbon nanomaterials (CNMs) are investigated as potential carriers of ⁶⁸Ga, which is widely used in positron emission tomography (PET) in nuclear medicine. Sorption behavior of ⁶⁸Ga was studied onto CNMs of various structures and chemical compositions: nanodiamonds (ND), reduced graphite oxide (rGiO) and multi-walled carbon nanotubes (MWCNT), as well as their oxidized (ND-COOH) or reduced (rGiO-H, MWCNT-H) forms. The physicochemical properties of the nanoparticles were determined by high resolution transmission electron microscopy, x-ray photoelectron spectroscopy, dynamic light scattering and potentiometric titration. The content of ⁶⁸Ga in the solutions during the study of sorption was determined by gamma-ray spectrometry. The highest degree of ⁶⁸Ga sorption was observed on ND and ND-COOH samples, and the optimal sorption conditions were determined: an aqueous solution with a pH of 5-7, m/V ratio of 50 μg/mL and a room temperature (25 °C). The ⁶⁸Ga@ND and ⁶⁸Ga@ND-COOH conjugates were found to be stable in a model blood solution-phosphate-buffered saline with a pH of 7.3, containing 40 g/L of bovine serum albumin: ⁶⁸Ga desorption from these samples in 90 minutes was no more than 20% at 25 °С and up to 30% at 37 °С. Such a quantity of desorbed ⁶⁸Ga does not harm the body and does not interfere with the PET imaging process. Thus, ND and ND-COOH are promising CNMs for using as carriers of ⁶⁸Ga for PET diagnostics.