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The Characterization of Ground Raspberry Seeds and the Physiological Response to Supplementation in Hypertensive and
Michał Majewski1, Ewa Kucharczyk1, Roman Kaliszan2
1Department of Pharmacology and Toxicology, Faculty of Medicine, UWM, 10-082 Olsztyn, Poland.
Nutrients
|June 5, 2020
Summary
Ground raspberry seeds (RBS), rich in polyphenols, improved antioxidant status and vasodilation in rats. These findings suggest RBS may help prevent cardiovascular diseases.
Area of Science:
- Cardiovascular Science
- Nutritional Biochemistry
- Pharmacology
Background:
- Ground raspberry seeds (RBS) are a rich source of polyphenols and essential fatty acids.
- Polyphenols and essential fatty acids are known for their antioxidant and cardiovascular benefits.
- Understanding the specific mechanisms of RBS in cardiovascular health is crucial.
Purpose of the Study:
- To evaluate the protective effects of ground raspberry seeds (RBS) on antioxidant status, lipid profile, and vasodilation.
- To investigate the role of RBS in both normotensive and hypertensive rat models.
- To elucidate the potential mechanisms underlying RBS's cardiovascular benefits.
Main Methods:
- Young Wistar-Kyoto rats (WKYs) and spontaneously hypertensive rats (SHRs) were fed a control diet or a diet supplemented with 7% RBS for six weeks.
- Blood plasma enzymatic antioxidant status, lipid profile, and endothelium-intact vasodilation were assessed.
- Specific enzyme inhibitors were used to investigate the pathways involved in vasodilation.
Main Results:
- Ground RBS decreased liver enzymes (aspartate aminotransferase) and hydrogen peroxide scavenging capacity (Catalase) in both rat models.
- In hypertensive rats, RBS supplementation reversed the effects of various enzyme inhibitors on vasodilation.
- In normotensive rats, RBS decreased the atherogenic index and enhanced vasodilation mediated by inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2)-derived prostacyclin (PGI2).
Conclusions:
- Ground RBS exhibits cardioprotective effects by modulating antioxidant status and improving endothelial function.
- RBS may exert its benefits through pathways involving iNOS and COX-2-derived PGI2.
- These findings suggest ground raspberry seeds hold potential for cardiovascular disease prevention.
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