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Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

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Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

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Gender Differences in Medication Use: A Drug Utilization Study Based on Real World Data.

Valentina Orlando^1,2, Sara Mucherino^1,2, Ilaria Guarino¹

¹CIRFF, Center of Pharmacoeconomics and Drug utilization Research, University of Naples Federico II, 80131 Naples, Italy.

International Journal of Environmental Research and Public Health

|June 5, 2020

Summary

This study found significant gender differences in drug use, with females having more prescriptions but males having longer treatment durations and higher costs. These findings highlight the need for personalized medicine approaches.

Keywords:

drug cost drug utilization study gender difference medication use prescription pattern real-world data

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Published on: November 21, 2013

Area of Science:

Pharmacology
Public Health
Health Services Research

Background:

Understanding gender-specific patterns in medication use is crucial for optimizing healthcare.
Previous research indicates potential disparities in drug utilization between genders.

Purpose of the Study:

To investigate gender differences in outpatient drug utilization in the Campania region, Southern Italy.
To analyze prevalence, therapeutic group distribution, treatment duration, and associated costs based on gender.

Main Methods:

A retrospective drug utilization study using administrative prescription data from 2018.
Inclusion of all patients with at least one drug prescription.
Prevalence calculation to assess drug exposure, with analysis of Anatomical Therapeutic Chemical (ATC) II classification.

Main Results:

Out of 3,899,360 patients, 54.2% were female, receiving 55.6% of all prescriptions.
Females showed higher prevalence for anti-inflammatory, beta-blockers, psychoanaleptics, and antianemic drugs.
Males exhibited higher prevalence for diabetes medications, particularly biguanides, with longer treatment durations and higher mean costs per patient.

Conclusions:

Substantial gender disparities exist in medication use patterns, treatment duration, and healthcare costs.
These findings underscore the importance of gender-specific considerations in pharmacotherapy.
The results support the advancement of precision and personalized medicine strategies.