Serum Calcification Propensity and the Risk of Cardiovascular and All-Cause Mortality in the General Population: The...

Vascular calcification contributes to the cause of cardiovascular disease. The calciprotein particle maturation time (T₅₀) in serum, a measure of calcification propensity, has been linked with adverse outcomes in patients with chronic kidney disease, but its role in the general population is unclear. We investigated whether serum T₅₀ is associated with cardiovascular mortality in a large general population-based cohort. Approach and Results: The relationship between serum T₅₀ and cardiovascular mortality was studied in 6231 participants of the PREVEND (Prevention of Renal and Vascular End-Stage Disease) cohort. All-cause mortality was the secondary outcome. Mean (±SD) age was 53±12 years, 50% were male, and mean serum T₅₀ was 329±58 minutes. A shorter serum T₅₀ is indicative of a higher calcification propensity. Serum T₅₀ was inversely associated with circulating phosphate, age, estimated glomerular filtration rate, and alcohol consumption, whereas plasma magnesium was positively associated with serum T₅₀ (P<0.001, total multivariable model R²=0.281). During median (interquartile range) follow-up for 8.3 (7.8-8.9) years, 364 patients died (5.8%), of whom 95 (26.1%) died from a cardiovascular cause. In multivariable Cox proportional hazard models, each 60 minutes decrease in serum T₅₀ was independently associated with a higher risk of cardiovascular mortality (fully adjusted hazard ratio [95% CI], 1.22 [1.04-1.36], P=0.021). This association was modified by diabetes mellitus; stratified analysis indicated a more pronounced association in individuals with diabetes mellitus.

Serum T₅₀ is independently associated with an increased risk of cardiovascular mortality in the general population and thus may be an early and potentially modifiable risk marker for cardiovascular mortality.