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Updated: Dec 19, 2025
Methods to Study Lipid Alterations in Neutrophils and the Subsequent Formation of Neutrophil Extracellular Traps
Published on: March 29, 2017
Variability in blood lipids affects the neutrophil to lymphocyte ratio in patients undergoing elective percutaneous
Liding Zhao1,2, Tian Xu1,2, Ya Li1,2
1Department of Cardiovascular Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, No 3 East of Qinchun Road, Hangzhou, Zhejiang, 310000, People's Republic of China.
Insights
Blood lipid variability, specifically in high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), significantly impacts neutrophil-to-lymphocyte ratio (NLR) values and their variability. These lipid variations are identified as key risk factors for inflammation markers in patients.
Area of Science:
- Cardiovascular Research
- Inflammation Biomarkers
- Lipid Metabolism
Background:
- Atherosclerosis is linked to chronic inflammation and altered lipid metabolism.
- The neutrophil-to-lymphocyte ratio (NLR) indicates inflammation and predicts cardiovascular disease prognosis.
- The impact of blood lipid variability on NLR remains underexplored.
Purpose of the Study:
- To investigate the relationship between blood lipid variability and NLR.
- To determine if lipid variability influences inflammation markers like NLR.
Main Methods:
- Univariate and multivariate linear regression analyses were employed.
- Subgroup analyses were conducted to validate findings across different patient groups.
Main Results:
- Variability in high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels were significant risk factors for NLR values.
- Lipid variability, not baseline levels, predicted NLR values and variability.
- HDL-C variability showed a more consistent association with NLR across subgroups compared to LDL-C variability.
Conclusions:
- Variability in HDL-C and LDL-C are risk factors for NLR values and variability.
- HDL-C variability demonstrates a more stable association with NLR than LDL-C variability.
- Managing lipid variability may offer a novel strategy for controlling inflammation in patients, particularly those undergoing percutaneous coronary intervention (PCI).
Background:
Atherosclerosis is associated with chronic inflammation and lipid metabolism. The neutrophil to lymphocyte ratio (NLR) as an indicator of inflammation has been confirmed to be associated with cardiovascular disease prognosis. However, few studies have explored the effects of blood lipid variability on NLR. The aim of this study was to explore the relationship between variability in blood lipid levels and NLR.
Methods:
The association between variability in blood lipids and NLR was assessed with both univariate and multivariate linear regression. Multivariate linear regression was also performed for a subgroup analysis.
Results:
The variability of high-density lipoprotein cholesterol (HDL-C) (regression coefficients [β] 4.008, standard error (SE) 0.503, P-value< 0.001) and low-density lipoprotein cholesterol (LDL-C) ([β] 0.626, SE 0.164, P-value< 0.001) were risk factors for the NLR value, although baseline LDL-C and HDL-C were not risk factors for NLR values. Variability of HDL-C ([β] 4.328, SE 0.578, P-value< 0.001) and LDL-C ([β] 0.660, SE 0.183, P-value< 0.001) were risk factors for NLR variability. Subgroup analysis demonstrated that the relationship between variability of LDL-C and NLR was consistent with the trend of the total sample for those with diabetes mellitus, controlled blood lipid, statins, atorvastatin. The relationship between the variability of HDL-C and NLR was consistent with the trend of the total sample in all subgroups.
Conclusion:
The variability of HDL-C and LDL-C are risk factors for the value and variability of NLR, while the relationship between variability of HDL-C and NLR is more stable than the variability of LDL-C in the subgroup analysis, which provides a new perspective for controlling inflammation in patients undergoing PCI.
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