[Clinical evaluation of sultamicillin fine granules in lower respiratory tract infection]
M Takamoto1, S Harada, Y Harada
1Department of Internal Medicine, Ohmuta National Hospital.
Abstract:
Sultamicillin (SBTPC) fine granules were given to 15 patients with respiratory tract infections at a dose of 375 mg 3 times a day. The results were excellent in 4 patients, good in 8, fair in 1 and poor in 2 with an efficacy rate of 80% which is comparable to that of SBTPC tablet (Unasyn tablet). One patient complained of difficulty in swallowing the drug probably due to its fine granular nature. No side effects nor abnormal laboratory test values due to this drug were observed in any of the patients enrolled in this study. From the above results, SBTPC fine granules seem to be useful in the treatment of pediatric and elderly patients who sometimes have difficulties in taking tablets.
Insights
Sultamicillin (SBTPC) fine granules demonstrated an 80% efficacy rate in treating respiratory infections, comparable to tablets. This formulation may benefit pediatric and elderly patients with swallowing difficulties.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Infectious Diseases
Context:
- Respiratory tract infections (RTIs) pose a significant health burden.
- Sultamicillin (SBTPC) is a commonly prescribed antibiotic for bacterial infections.
- Challenges exist in drug administration for pediatric and elderly populations.
Purpose:
- To evaluate the efficacy and tolerability of sultamicillin (SBTPC) fine granules in patients with RTIs.
- To compare the performance of SBTPC fine granules with the standard SBTPC tablet formulation.
- To assess the suitability of SBTPC fine granules for specific patient demographics.
Summary:
- A study involving 15 patients with RTIs administered SBTPC fine granules at 375 mg thrice daily.
- An 80% efficacy rate was observed (4 excellent, 8 good, 1 fair, 2 poor), comparable to SBTPC tablets.
- One patient reported minor swallowing difficulty; no significant adverse effects or laboratory abnormalities were noted.
Impact:
- SBTPC fine granules show promise as an effective alternative for treating RTIs, particularly in patients who struggle with tablet ingestion.
- The fine granule formulation offers a potentially more convenient administration route for pediatric and geriatric patients.
- Further research could explore broader applications and long-term outcomes of this formulation.
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