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Updated: Dec 19, 2025

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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Stroke as a complication and prognostic factor of COVID-19

J M Trejo-Gabriel-Galán1

  • 1Servicio de Neurología, Hospital Universitario de Burgos, Burgos, España.

Neurologia
|June 5, 2020
PubMed

Insights

A history of stroke triples the risk of death in COVID-19 patients. While stroke is not a primary complication of COVID-19, it significantly impacts patient outcomes.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Public Health

Background:

  • Conflicting data exist regarding stroke incidence in COVID-19 patients.
  • The risk of SARS-CoV-2 infection in individuals with a prior stroke history is unclear.

Purpose of the Study:

  • To systematically review stroke as a COVID-19 complication.
  • To analyze the prognosis of COVID-19 patients with a history of stroke.
  • To review the pathophysiological mechanisms of stroke in COVID-19.

Main Methods:

  • Systematic review of case series on stroke complications in COVID-19.
  • Analysis of prognosis in COVID-19 patients with prior stroke.
  • Review of pathophysiological mechanisms linking COVID-19 and stroke.

Main Results:

  • A history of stroke increases the risk of death from COVID-19 by threefold.
  • Stroke is not identified as a predominant complication of COVID-19.

Conclusions:

  • Prior stroke history is a significant risk factor for COVID-19 mortality.
  • Further research into the relationship between stroke and COVID-19 is warranted.
Abstract

Keywords:
COVID-19Cerebrovascular diseasesCoronavirus infectionEnfermedades cerebrovascularesInfección coronavirusSARS-CoV-2

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