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Long non-coding RNA MEG3 is involved in osteogenic differentiation and bone diseases (Review)

Hong Sun1, Guoxuan Peng2, Hongbin Wu1

  • 1Department of Orthopaedics, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China.

Biomedical Reports
|June 5, 2020
PubMed

Insights

Maternally expressed gene 3 (MEG3) long non-coding RNA plays a key role in bone formation by regulating mesenchymal stem cell differentiation. Understanding MEG3

Area of Science:

  • * Molecular Biology and Genetics
  • * Stem Cell Biology
  • * Bone Metabolism and Disease

Background:

  • * Osteogenic differentiation of mesenchymal stem cells (MSCs) is a complex process involving transcriptional factors, signaling pathways, and biomechanical cues.
  • * Disruptions in these networks can affect MSC and osteoblast proliferation and apoptosis, leading to impaired bone metabolism and homeostasis.
  • * Long non-coding RNAs (lncRNAs) are increasingly recognized for their involvement in osteogenic differentiation and bone diseases like osteoporosis and osteoarthritis.

Purpose of the Study:

  • * To review the proposed mechanisms by which the lncRNA maternally expressed gene 3 (MEG3) influences osteogenic differentiation.
  • * To discuss the potential role of MEG3 in the development and progression of bone diseases.
  • * To highlight MEG3 as a potential biomarker and therapeutic target for bone-related conditions.

Main Methods:

  • * Comprehensive literature review of studies investigating the role of MEG3 in osteogenic differentiation.
  • * Analysis of proposed molecular mechanisms and signaling pathways involving MEG3.
  • * Examination of evidence linking MEG3 to bone diseases such as tumors, osteoarthritis, and osteoporosis.

Main Results:

  • * MEG3 is confirmed to regulate osteogenic differentiation in various MSC types.
  • * MEG3 acts as a critical mediator in bone formation processes.
  • * Dysregulation of MEG3 is implicated in the pathogenesis of several bone diseases.

Conclusions:

  • * MEG3 plays a significant role in osteogenic differentiation and bone homeostasis.
  • * Further elucidation of MEG3's mechanisms can provide insights into bone disease development.
  • * MEG3 presents potential as a diagnostic biomarker and therapeutic target for bone diseases.
Keywords:
bone diseaseslong non-coding RNAsmaternally expressed gene 3osteogenic differentiation

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