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Related Experiment Video

Updated: Dec 19, 2025

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle
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Super-resolution nanoscopy by coherent control on nanoparticle emission.

Congyue Liu1, Wei Liu1, Shufeng Wang1,2,3

  • 1State Key Laboratory for Artificial Microstructure and Mesoscopic Physics, Department of Physics, Peking University, Beijing 100871, China.

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|June 5, 2020
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Summary

This study introduces a novel super-resolution nanoscopy technique achieving ~50 nm resolution by modulating emitter fluorescence. This method enhances efficiency and suppresses noise in wide-field imaging without sacrificing speed.

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Area of Science:

  • Optics and Photonics
  • Biophysics
  • Materials Science

Background:

  • Wide-field microscopic imaging offers high efficiency but limited resolution.
  • Super-resolution nanoscopy aims to overcome diffraction limits for detailed cellular and material imaging.

Purpose of the Study:

  • To develop a general strategy for achieving ~50 nm resolution in wide-field nanoscopy.
  • To maintain the high efficiency of wide-field imaging while significantly improving resolution.
  • To suppress noise and enhance imaging quality in dense emitter scenarios.

Main Methods:

  • Utilizing excited state coherent control on single-particle two-photon fluorescence.
  • Actively and simultaneously modulating the emission characteristics of individual emitters.
  • Applying the principle to dense samples, including quantum dot-labeled films and biological cells.

Main Results:

  • Achieved a resolution of approximately 50 nm, comparable to single molecular localization microscopy.
  • Demonstrated simultaneous noise suppression, improving image clarity.
  • Verified the method's efficacy through simulations and experimental validation.

Conclusions:

  • The developed strategy provides a general approach to enhance resolution in wide-field nanoscopy.
  • Coherent control principles are broadly applicable to multiphoton imaging and diverse probes.
  • This technique offers a powerful tool for high-resolution imaging without compromising efficiency.