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IL17F rs763780 single nucleotide polymorphism is associated with asthma after bronchiolitis in infancy

Annukka Holster1, Johanna Teräsjärvi2, Alex-Mikael Barkoff2

  • 1Center for Child Health Research, Faculty of Medicine and Life Sciences, University of Tampere and University Hospital, Tampere, Finland.

Acta Paediatrica (Oslo, Norway : 1992)
|June 5, 2020
PubMed

Insights

This study investigated Interleukin-17F (IL-17F) gene variations and childhood asthma risk following infant bronchiolitis. The IL17F rs763780 polymorphism was linked to increased asthma medication use and atopic dermatitis in children.

Area of Science:

  • Immunogenetics
  • Pediatric Respiratory Medicine
  • Allergy and Immunology

Background:

  • Interleukin-17F (IL-17F) is implicated in asthma pathogenesis.
  • Infant bronchiolitis is a significant risk factor for developing childhood asthma.
  • Genetic predispositions, including IL-17F polymorphisms, may influence asthma development post-bronchiolitis.

Purpose of the Study:

  • To evaluate the association between specific IL17F gene polymorphisms (rs763780, rs11465553, rs7741835) and the risk of childhood asthma.
  • To assess these genetic associations in children with a history of bronchiolitis in infancy.
  • To determine if IL17F variations correlate with asthma and allergy outcomes at school age.

Main Methods:

  • A prospective long-term follow-up study included 166 children hospitalized for bronchiolitis before six months of age.
  • Children attended follow-up visits at 5-7 and 11-13 years of age for asthma and allergy assessments.
  • Genotyping for IL17F polymorphisms rs763780, rs11465553, and rs7741835 was performed on blood samples from 165 participants.

Main Results:

  • No significant association was found between IL17F rs11465553 or rs7741835 and asthma or allergy outcomes.
  • Children with the variant IL17F rs763780 genotype showed significantly higher use of inhaled corticosteroids (ICSs) between ages 5-7 and 11-13 years (adjusted OR 3.58).
  • The variant IL17F rs763780 genotype was also associated with a higher reported incidence of doctor-diagnosed atopic dermatitis at 11-13 years (adjusted OR 2.71).

Conclusions:

  • The IL17F rs763780 polymorphism may be associated with asthma development and related allergic conditions in children with a history of infant bronchiolitis.
  • This finding provides preliminary evidence linking specific IL-17F genetic variations to long-term respiratory health outcomes.
  • Further research is warranted to elucidate the precise role of IL17F rs763780 in the trajectory from infant bronchiolitis to childhood asthma.
Abstract

Keywords:
Interleukin-17Fatopic dermatitisbronchiolitischildhood asthmasingle nucleotide polymorphism

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